Product Name	Annexin V
Chinese Name	膜粘连蛋白5Recombinant rabbit monoclonal anti
Research Area	Tumour  Cell biology  immunology  Signal transduction  Apoptosis
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	6C7
React Species	Human, Mouse, Rat,
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	36kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Annexin V
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq, Jul 2008]. Function: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Subunit: Monomer. Binds ATRX and EIF5B. Interacts with hepatitis B virus (HBV). Subcellular Location: Monomer. Binds ATRX and EIF5B. Interacts with hepatitis B virus (HBV). Post-translational modifications: S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex. DISEASE: Defects in ANXA5 are associated with susceptibility to pregnancy loss, recurrent, type 3 (RPRGL3) [MIM:614391]. A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions. Similarity: Belongs to the annexin family. Contains 4 annexin repeats. SWISS: P08758 Gene ID: 308 Database links: Entrez Gene: 308 Human Entrez Gene: 11747 Mouse Entrez Gene: 25673 Rat Omim: 131230 Human SwissProt: P08758 Human SwissProt: P48036 Mouse SwissProt: P14668 Rat Unigene: 480653 Human Unigene: 1620 Mouse Unigene: 3318 Rat
Product Picture	Sample: Lane 1: Lung (Mouse) Lysate at 40 ug Lane 2: Placenta (Mouse) Lysate at 40 ug Lane 3: Uterus (Mouse) Lysate at 40 ug Lane 4: Spleen (Mouse) Lysate at 40 ug Lane 5: Stomach (Mouse) Lysate at 40 ug Lane 6: Lung (Rat) Lysate at 40 ug Lane 7: Uterus (Rat) Lysate at 40 ug Lane 8: Spleen (Rat) Lysate at 40 ug Lane 9: Stomach (Rat) Lysate at 40 ug Lane 10: HepG2 (Human) Cell Lysate at 30 ug Lane 11: Panc-1 (Human) Cell Lysate at 30 ug Lane 12: K562 (Human) Cell Lysate at 30 ug Lane 13: Jurkat (Human) Cell Lysate at 30 ug Lane 14: Huvec(Human) Cell Lysate at 30 ug Primary: Anti-Annexin V (SLM-52841R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 32 kD Observed band size: 34 kD

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