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Product Name NeuN Chinese Name 神经元核抗原Recombinant rabbit monoclonal anti Alias RFOX3_HUMAN; RNA binding protein fox-1 homolog 3; RBFOX3; Fox-1 homolog C; Neuronal nuclei antigen (NeuN antigen); FOX3; FOX-3; HRNBP3; Research Area Cell biology Neurobiology Transporter Epigenetics Immunogen Species Rabbit Clonality Monoclonal Clone NO. 12C3 React Species Mouse, Rat, (predicted: Human, ) Applications WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:200-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 34kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human NeuN Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]
Function:
RNA-binding protein that regulates alternative splicing events.
Subcellular Location:
Nucleus. Cytoplasm.
Similarity:
Contains 1 RRM (RNA recognition motif) domain.
SWISS:
A6NFN3
Gene ID:
146713
Database links:Entrez Gene: 146713 Human
Entrez Gene: 52897 Mouse
SwissProt: A6NFN3 Human
SwissProt: Q8BIF2 Mouse
Unigene: 135229 Human
Unigene: 341103 Mouse
Unigene: 143966 Rat
Product Picture Sample:
Lane 1: Mouse Cerebrum tissue lysates
Lane 2: Mouse Cerebellum tissue lysates
Lane 3: Rat Cerebrum tissue lysates
Lane 4: Rat Cerebellum tissue lysates
Primary: Anti-NeuN (SLM-52268R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 34 kDa
Observed band size: 45,48 kDa
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