Product Name	HIF-1 beta
Chinese Name	缺氧诱导因子1β/HIF-1βRecombinant rabbit monoclonal anti
Alias	HIF1 beta; ARNT1; ARNT; HIF 1 beta; HIF-1 Beta; ARNT protein; Aryl Hydrocarbon Receptor Nuclear Translocator ; Dioxin Receptor; Dioxin receptor nuclear translocator; Drnt; HIF 1 beta;HIF 1beta; HIF1B; HIF1beta; Hypoxia Inducible Factor 1; Hypoxia inducible factor 1 beta; Tango; ARNT_HUMAN; Class E basic helix-loop-helix protein 2; bHLHe2; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta; HIF-1 β; HIF1-β; HIF 1-β; HIF-1-β; HIF 1 β; HIF1β; HIF1 β; HIF1-β; HIF 1β.
Research Area	Tumour  Cardiovascular  Chromatin and nuclear signals  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	3F5
React Species	Human, Mouse, Rat,
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	87kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HIF-1 beta
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Function: Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia. Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with AHR, AHRR, HIF1A and EPAS1/HIF2A as well as with other bHLH proteins. Interacts with TACC3. Interacts with NOCA7. Heterodimer with HIF1A. Subcellular Location: Nucleus. Similarity: Contains 1 bHLH (basic helix-loop-helix) domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 2 PAS (PER-ARNT-SIM) domains. SWISS: P27540 Gene ID: 405 Database links: Entrez Gene: 405 Human Entrez Gene: 11863 Mouse Entrez Gene: 25242 Rat Omim: 126110 Human SwissProt: P27540 Human SwissProt: P53762 Mouse SwissProt: P41739 Rat Unigene: 632446 Human Unigene: 250265 Mouse Unigene: 10520 Rat

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