Product Name	ADAM17 (9E7)
Chinese Name	ADAM17Recombinant rabbit monoclonal anti
Alias	A disintegrin and metalloproteinase domain 17; ADAM 17; ADAM metallopeptidase domain 17; ADAM17 protein; CD 156b; CD156b; CD156b antigen; CSVP; MGC71942; Snake venom like protease; TACE; TNF alpha convertase; TNF alpha converting enzyme; Tumor Necrosis Factor Alpha Converting Enzyme; A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); ADA17_HUMAN.
literatures	Specific References  (1)     |     SLM-52009R has been referenced in 1 publications. [IF=16.988] Wu Yutong. et al. Osteoclast-Derived Apoptotic Bodies Inhibit Naive Cd8 T Cell Activation via Siglec15 Promoting Breast Cancer Secondary Metastasis. Cell Reports Medicine. 2022 Nov 03  WB ;  Mouse.   PubMed:10.2139/ssrn.4255228
Research Area	Tumour  immunology  Neurobiology  Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Monoclonal
Clone NO.	9E7
React Species	Human, Mouse,  (predicted: Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:20-200 IF=1:20-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	93kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human ADAM17 protein: 700-824/824 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq]. Subunit: Interacts with MAD2L1, MAPK14 and MUC1. Subcellular Location: Membrane. Tissue Specificity: Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney. Similarity: Contains 1 disintegrin domain. Contains 1 peptidase M12B domain. SWISS: P78536 Gene ID: 6868 Database links: Entrez Gene: 6868 Human Entrez Gene: 11491 Mouse Entrez Gene: 57027 Rat Omim: 603639 Human SwissProt: P78536 Human SwissProt: Q9Z0F8 Mouse SwissProt: Q9Z1K9 Rat Unigene: 404914 Human Unigene: 27681 Mouse Unigene: 144585 Rat
Product Picture	Sample: Pancreas (Mouse) Lysate at 40 ug Primary: Anti-ADAM17 (9E7) (SLM-52009R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 93 kD Observed band size: 93 kD Sample: Spleen (Mouse) Lysate at 40 ug Jurkat(Human) Cell Lysate at 30 ug SW480(Human) Cell Lysate at 30 ug Primary: Anti- ADAM17 (9E7) (SLM-52009R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 93 kD Observed band size: 100 kD

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