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Product Name SULT1A1 Chinese Name SULT1A1单克隆抗体 Alias ST1A1_HUMAN; SULT6B1; Aryl sulfotransferase 1; HAST1/HAST2; Human aryl sulfotransferase mRNA complete cds; P PST 1; P PST; P-PST 1; Phenol sulfating phenol sulfotransferase 1; Phenol sulfotransferase 1; Phenol-sulfating phenol sulfotransferase 1; PST; ST1A1; ST1A3; STP; STP1; Sulfotransferase 1A1; Sulfotransferase family 1A phenol preferring member 1; Sulfotransferase family cytosolic 1A phenol preferring member 1; Sulfotransferase phenol preferring 1; Thermostable phenol sulfotransferase; Ts PST; Ts-PST; TSPST1. Research Area Tumour Signal transduction TumourCell biologyMaker The new supersedes the old Immunogen Species Mouse Clonality Monoclonal Clone NO. C10G4 React Species Human, Mouse, Rat, Applications WB=1:500-1000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 34 kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen Recombinant human ST1A1. Lsotype IgG1,κ Purification affinity purified by Protein G Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene.
Function:
Catalyzes the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.
Subunit:
Homodimer.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Liver, lung, adrenal, brain, platelets and skin.
Post-translational modifications:
Substrate for botulinum ADP-ribosyltransferase.
Cleaved by yopT protease when the cell is infected by some Yersinia pathogens. This removes the lipid attachment, and leads to its displacement from plasma membrane and to subsequent cytoskeleton cleavage.
AMPylation at Tyr-34 and Thr-37 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.
Phosphorylation by PRKG1 at Ser-188 inactivates RHOA signaling.
Ubiquitinated by the BCR(BACURD1) and BCR(BACURD2) E3 ubiquitin ligase complexes, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration.
Similarity:
Belongs to the sulfotransferase 1 family.
SWISS:
P50225
Gene ID:
6817
Database links:Entrez Gene: 6817 Human
Entrez Gene: 20887 Mouse
SwissProt: P50225 Human
SwissProt: P52840 Mouse
Product Picture Sample:
Lane 1: HepG2 cell lysates
Primary: Anti-SULT1A1 (SLM-51747M) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 34 kD
Observed band size: 30 kD
Sample:
Lane 1: HepG2 cell lysates
Lane 2: Human lung tissue lysates
Lane 3: Human liver tissue lysates
Lane 4: Mouse liver tissue lysates
Lane 5: Mouse kidney tissue lysates
Lane 6: Rat kidney tissue lysates
Primary: Anti-SULT1A1 (SLM-51747M) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 34 kD
Observed band size: 30 kD
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