Product Name	PURB
Chinese Name	转录激活蛋白PURB单克隆抗体
Alias	Pur beta; PURB_HUMAN; PURBETA; Purine rich element binding protein B; Purine-rich element-binding protein B; transcriptional activator protein Pur beta; Transcriptional activator protein Pur-beta.
Research Area	Chromatin and nuclear signals  transcriptional regulatory factor  Epigenetics
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	F4D9
React Species	Human, Mouse,
Applications	WB=1:1000-4000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	33kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human PURB.
Lsotype	IgG1,κ
Purification	affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008] Function: Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs. Subunit: Homodimer, heterodimer with PURA and heterotrimer with PURA and YBX1/Y-box protein 1. Subcellular Location: Nucleus. Tissue Specificity: Expressed in myocardium of heart failure patients. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the PUR DNA-binding protein family. SWISS: Q96QR8 Gene ID: 5814 Database links: Entrez Gene: 5814 Human Entrez Gene: 19291 Mouse SwissProt: Q96QR8 Human SwissProt: O35295 Mouse
Product Picture	Sample: Lane 1: Jurkat cell lysates Lane 2: HeLa cell lysates Lane 3: NCI-H460 cell lysates Lane 4: HepG2 cell lysates Lane 5: MCF-7 cell lysates Lane 6: NIH/3T3 cell lysates Primary: Anti-PURB (SLM-51738M) at 1/8000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 33 kD Observed band size: 37 kD

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