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Product Name FOLR2 Chinese Name 胎盘叶酸受体蛋白2单克隆抗体 Alias Folate receptor beta; fetal/placental; Folbp 2; beta hFR; FBP; FBP/PL 1; FBP2; folate receptor 2 (fetal); Folate receptor 2; Folate receptor; Folate receptor, fetal/placental; Folbp2; FOLR2_HUMAN; FR beta; FR P3; FR-beta; Placental folate binding protein; Placental folate-binding protein. Research Area Cell biology The new supersedes the old Immunogen Species Mouse Clonality Monoclonal Clone NO. F4E5 React Species Human, Applications WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 25kDa Cellular localization The cell membrane Secretory protein Form Liquid Concentration 1mg/ml immunogen Recombinant human FOLR2. Lsotype IgG2b,κ Purification affinity purified by Protein G Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
Subcellular Location:
Cell membrane. Secreted.
Tissue Specificity:
Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.
Post-translational modifications:
Eight disulfide bonds are present.
N-glycosylated.
Similarity:
Belongs to the folate receptor family.
SWISS:
P14207
Gene ID:
2350
Database links:Entrez Gene: 2350 Human
SwissProt: P14207 Human
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