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Product Name Adenylate Kinase 1 Chinese Name 腺苷酸激酶-1单克隆抗体 Alias AK 1; AK1; AK-1; KAD1_HUMAN; Adenylate kinase isoenzyme 1; Adenylate kinase soluble; ATP AMP transphosphorylase; Myokinase; ATP-AMP transphosphorylase 1. Research Area Tumour Cardiovascular Signal transduction The new supersedes the old Immunogen Species Mouse Clonality Monoclonal Clone NO. G6E1 React Species Human, Applications WB=1:500-4000 IHC-P=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 21kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen Recombinant human AK1 between 1-193 amino acids. Lsotype IgG1,k Purification affinity purified by Protein G Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Function:
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth.
Subunit:
Monomer.
Subcellular Location:
Cytoplasm.
DISEASE:
Defects in AK1 are the cause of hemolytic anemia due to adenylate kinase deficiency (HAAKD) [MIM:612631].
Similarity:
Belongs to the adenylate kinase family.
SWISS:
P00568
Gene ID:
203
Database links:Entrez Gene: 203 Human
SwissProt: P00568 Human
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