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Product Name Neurogenin3 Chinese Name 神经元素3单克隆抗体 Alias NGN3; NGN-3; neurogenin 3; Neurog3; Neurogenin-3; ATH4B; Atoh5; Math4B; NEUROG3; ngn3; OTTHUMP00000019730; Protein atonal homolog 5; Class A basic helix-loop-helix protein 7; NGN3_HUMAN. Research Area Cell biology Neurobiology transcriptional regulatory factor Epigenetics Immunogen Species Mouse Clonality Monoclonal Clone NO. F11S3 React Species Human, Applications WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 23kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen Recombinant human Neurogenin3 between 1-214 amino acids. Lsotype IgG2a,k Purification affinity purified by Protein G Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Neurogenin-3 (NEUROG3) is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine (Wang et al., 2006 [PubMed 16855267]). It belongs to a family of basic helix-loop-helix transcription factors involved in the determination of neural precursor cells in the neuroectoderm.
Function:
Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types.
Subcellular Location:
Nucleus.
DISEASE:
Defects in NEUROG3 are the cause of diarrhea type 4 (DIAR4) [MIM:610370]. DIAR4 is a characterized by severe, life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells.
Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.
SWISS:
Q9Y4Z2
Gene ID:
50674
Database links:Entrez Gene: 50674 Human
SwissProt: Q9Y4Z2 Human
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