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Product Name ITGA11 Chinese Name 整合素α11单克隆抗体 Alias integrin a11; Integrin alpha 11; Integrin alpha-11; ITA11_HUMAN; Integrin α11. Research Area Tumour Cell biology Signal transduction Immunogen Species Mouse Clonality Monoclonal Clone NO. N4F2 React Species Human, Applications WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 131kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human ITGA11: 651-850/1188 <Extracellular> Lsotype IgG2b,k Purification affinity purified by Protein G Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Integrins are heterodimers composed of noncovalently associated transmembrane alpha and beta subunits, which heterodimerize to produce more than 20 different receptors. Most Integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen (COL) and Vitronectin. Certain Integrins can also bind to soluble ligands, such as Fibrinogen, or to counterreceptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), leading to cellular aggregation. Integrin ?1, also known as ITGA11 or MSTP018, is a 1,189 amino acid single-pass type I membrane protein that contains one VWFA domain and seven FG-GAP repeats. Expressed at high levels in heart and uterus and present at lower levels in pancreas, kidney, skeletal muscle, placenta, lung, colon and brain, Integrin alpha 11 exists as a heterodimer with Integrin beta1 and functions as a receptor for collagen.
Function:
Integrin alpha-11/beta-1 is a receptor for collagen.
Subcellular Location:
Membrane.
Tissue Specificity:
According to PubMed:10464311, highest levels of expression in uterus and heart, intermediate levels in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to PubMed:10486209, also found in brain, colon, lung, small intestine, stomach, testis, salivary glands, thyroid glands and prostate. Very low levels in peripheral blood lymphocytes, fetal brain and fetal liver.
Similarity:
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.
SWISS:
Q9UKX5
Gene ID:
22801
Database links:Entrez Gene: 22801 Human
SwissProt: Q9UKX5 Human
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