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Product Name USP2 Chinese Name Ubiquitin羧基末端水解酶2单克隆抗体 Alias 41 kDa ubiquitin specific protease ; 41 kDa ubiquitin-specific protease ; Deubiquitinating enzyme 2 ; Ubiquitin carboxyl terminal hydrolase 2 ; Ubiquitin carboxyl-terminal hydrolase 2 ; ubiquitin specific peptidase 2 ; Ubiquitin specific processing protease 2 ; Ubiquitin specific protease 12 ; Ubiquitin specific protease 9 ; Ubiquitin specific protease, 41kD ; Ubiquitin thioesterase 2 ; Ubiquitin thiolesterase 2 ; Ubiquitin-specific-processing protease 2 ; Ubiquitin-specific-processing protease testis ; UBP-t ; UBP2_HUMAN ; UBP41 ; USP9 Research Area Cell biology Signal transduction Kinases and Phosphatases Ubiquitin Immunogen Species Mouse Clonality Monoclonal Clone NO. K08F1 React Species Human, Monkey, Applications WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 68kDa Detection molecular weight 72 kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen Recombinant human USP2 Lsotype IgG1,k Purification affinity purified by Protein G Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Subcellular Location:
Cytoplasm and Cytosol
Tissue Specificity:
Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level).
SWISS:
O75604
Gene ID:
9099
Database links:
- Entrez Gene: 9099 Human
- Entrez Gene: 115771 Rat
- SwissProt: O75604 Human
Product Picture Sample:
Lane 1: MCF-7 cell lysates
Lane 2: PC-3 cell lysates
Lane 3: COS-7 cell lysates
Lane 4: Du145 cell lysates
Lane 5: SK-BR-3 cell lysates
Primary: Anti-USP2 (SLM-51636M) at 1/2000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 29 kD
Observed band size: 72 kD
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