Mouse Anti-AKAP13 antibody
A kinase (PRKA) anchor protein 13; A kinase anchor protein 13; A kinase anchoring protein; A-kinase anchor protein 13; AKAP 13; AKAP Lbc; AKAP-13; AKAP-Lbc; AKAP13; AKP13_HUMAN; ARHGEF13; Breast cancer nuclear receptor binding auxiliary protein; Breast ca
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Product Name AKAP13 Chinese Name 蛋白激酶锚定蛋白13单克隆抗体 Alias A kinase (PRKA) anchor protein 13; A kinase anchor protein 13; A kinase anchoring protein; A-kinase anchor protein 13; AKAP 13; AKAP Lbc; AKAP-13; AKAP-Lbc; AKAP13; AKP13_HUMAN; ARHGEF13; Breast cancer nuclear receptor binding auxiliary protein; Breast cancer nuclear receptor-binding auxiliary protein; BRX; c lbc; FLJ11952; FLJ43341; Guanine nucleotide exchange factor Lbc; HA 3; HA3; Ht 31; Ht31; Human thyroid anchoring protein 31; Human thyroid-anchoring protein 31; LBC; LBC oncogene; Lymphoid blast crisis oncogene; Non oncogenic Rho GTPase specific GTP exchange factor; Non-oncogenic Rho GTPase-specific GTP exchange factor; P47; Protein kinase A anchoring protein 13; Protein kinase A-anchoring protein 13; PROTO LB; PROTO LBC. Research Area Tumour Cell biology Signal transduction Kinases and Phosphatases G protein signal Immunogen Species Mouse Clonality Monoclonal Clone NO. G2S12 React Species (predicted: Human, ) Applications WB=1:500-4000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 307kDa Cellular localization The nucleus cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human AKAP13: 20-200/2813 Lsotype IgG1,k Purification affinity purified by Protein G Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element-specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Isoform 6 stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions.
Subcellular Location:
Cytoplasm; Cytoplasm. Nucleus and Membrane.
Tissue Specificity:
Isoform 3 and isoform 6 are found in hematopoietic cells, skeletal muscle, lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Isoform 6 is not found in brain, placenta, liver, pancreas or kidney. Isoform 7 is expressed in myeloid and lymphoid lineages, a variety of epithelial tissues and skeletal muscle. Isoform 2 is predominantly found in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver.
Similarity:
Contains 1 DH (DBL-homology) domain.
Contains 1 PH domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
SWISS:
Q12802
Gene ID:
11214
Database links:Entrez Gene: 11214 Human
SwissProt: Q12802 Human
Product Picture 
Sample:
Lane 1: Recombinant AKAP13 probein
Primary: Anti-AKAP13 (SLM-51633M) at 1/8000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 307 kD
Observed band size: 53 kD
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