Product Name	MAGED1
Chinese Name	黑色素瘤相关抗原D1单克隆抗体
Alias	DLXIN 1; MAGD1_HUMAN; MAGE D1 antigen; MAGE tumor antigen CCF; MAGE-D1 antigen; Melanoma antigen family D 1; Melanoma associated antigen D1; Melanoma-associated antigen D1; Neurotrophin receptor interacting MAGE homolog; Neurotrophin receptor-interacting MAGE homolog; NRAGE; PP2250.
Research Area	Tumour  Cell biology  immunology  Apoptosis
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	C5D3
React Species	Human,
Applications	WB=1:500-1000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	85kDa
Cellular localization	The nucleus cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MAGED1: 50-200/778
Lsotype	IgG1,κ
Purification	affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Involved in the apoptotic response after nerve growthfactor (NGF) binding in neuronal cells. Binds NGFR/p75NTR andantagonizes its association with NTRK1/TrkA, inhibits cell cycleprogression, and facilitates NGFR-mediated apoptosis. May act as aregulator of the function of DLX family members. May regulateTP53/p53 transcriptional activity and inhibit cell proliferation.Enhances TP53 phosphorylation and accumulation. May enhanceubiquitin ligase activity of RING-type zinc finger-containing E3ubiquitin-protein ligases. Proposed to act through recruitmentand/or stabilization of the Ubl-conjugating enzyme (E2) at theE3:substrate complex. Subunit: Interacts with DLX5, DLX7 and MSX2 and formshomomultimers. Interacts with UNC5A. Interacts withthe p75 neurotrophin receptor. Interacts with TRIM28 and PJA1. Subcellular Location: Cytoplasm. Cell membrane;Peripheral membrane protein. Note=Expression shiftsfrom the cytoplasm to the plasma membrane upon stimulation with NGF. Tissue Specificity: Expressed in bone marrow stromal cells fromboth multiple myeloma patients and healthy donors. Seems to beubiquitously expressed. Similarity: Contains 1 MAGE domain. SWISS: Q9Y5V3 Gene ID: 9500 Database links: Entrez Gene: 9500 Human SwissProt: Q9Y5V3 Human
Product Picture	Sample: Lane 1: Jurkat cell lysates Lane 2: 293 cell lysates Primary: Anti-MAGED1 (SLM-51582M) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 85 kD Observed band size: 110 kD

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