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Mouse Anti-TGF beta 2 antibody
Mouse Anti-TGF beta 2 antibody
Transforming growth factor beta-2 proprotein; TGFB2; TGF B2; BSC 1 cell growth inhibitor; BSC-1 cell growth inhibitor; BSC1 cell growth inhibitor; Cetermin; G TSF; G-TSF; Glioblastoma derived T cell suppressor ; Glioblastoma derived T cell suppressor fact
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  • NO.:SLM-51483M
    Clonality:Monoclonal
    Immunogen Species:Mouse
    React Species:Human,
    Applications:WB
    concentration:1mg/ml
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Product Name TGF beta 2
Chinese Name 转化生长因子β2(TGFβ2)单克隆抗体
Alias Transforming growth factor beta-2 proprotein; TGFB2; TGF B2; BSC 1 cell growth inhibitor; BSC-1 cell growth inhibitor; BSC1 cell growth inhibitor; Cetermin; G TSF; G-TSF; Glioblastoma derived T cell suppressor ; Glioblastoma derived T cell suppressor factor; Glioblastoma-derived T-cell suppressor factor; GTSF; MGC116892; Polyergin; TGF beta2; TGF-beta-2; TGF-beta2; TGFB 2; TGFB2_HUMAN; Transforming growth factor beta 2; Transforming growth factor beta-2.  
Research Area Tumour  Cell biology  Signal transduction  Stem cells  Growth factors and hormones  transcriptional regulatory factor  
Immunogen Species Mouse
Clonality Monoclonal
Clone NO. G1F2
React Species Human, 
Applications WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 50kDa
Cellular localization Secretory protein 
Form Liquid
Concentration 1mg/ml
immunogen Recombinant human TGF beta 2 
Lsotype IgG1,K
Purification affinity purified by Protein G
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail Transforming growth factor beta s (TGF beta s) were originally discovered due to their ability to promote anchorage-independent growth of rat NRK fibroblasts in the presence of TGF Alpha. It is now realized that TGF beta s mediate many cell-cell interactions that occur during embryonic development. Three TGF beta s have been identified in mammals. TGF beta 1, TGF beta 2 and TGF beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF beta requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF beta 3 protein has approximately 80% identity to the mature region of both TGF beta 1 and TGF beta 2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity.

Function:
TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.

Subunit:
Homodimer; disulfide-linked. Heterodimers with TGFB1 and with TGFB3 have been found in bone. Interacts with the serine proteases, HTRA1 and HTRA3. Interacts with ASPN.

Subcellular Location:
Secreted.

Similarity:
Belongs to the TGF-beta family.

SWISS:
P61812

Gene ID:
7042

Database links:

Entrez Gene: 7042 Human

SwissProt: P61812 Human



Product Picture
Sample:
Lane 1: A549 cell lysates
Primary: Anti-TGF beta 2 (SLM-51483M) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 50 kD
Observed band size: 52 kD
Sample:
Lane 1: MCF-7 cell lysates
Lane 2: Huvec cell lysates
Primary: Anti-TGF beta 2 (SLM-51483M) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 50 kD
Observed band size: 54 kD

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