Product Name	ALDH6A1
Chinese Name	ALDH6A1单克隆抗体
Alias	Aldehyde dehydrogenase 6 family member A1; Aldehyde dehydrogenase family 6 member A1; Aldehyde dehydrogenase family 6, subfamily A1; Malonate semialdehyde dehydrogenase; Malonate-semialdehyde dehydrogenase [acylating]; Methylmalonate semialdehyde dehydrogenase [acylating] mitochondrial; Methylmalonate-semialdehyde dehydrogenase [acylating]; MGC37325; MGC40271; Mitochondrial acylating methylmalonate semialdehyde dehydrogenase; mitochondrial; MMSA_HUMAN; MMSADHA; MMSDH;
Research Area	Signal transduction  Growth factors and hormones  The new supersedes the old
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	AL06
React Species	Human,
Applications	WB=1:500-1000 IHC-P=1:25 ICC=1:25 IF=1:25 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	59kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human ALDH6A1.
Lsotype	IgG1,IgK
Purification	affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded protein is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This protein catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] Function: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. Subunit: Homotetramer. Subcellular Location: Mitochondrion. Similarity: Belongs to the aldehyde dehydrogenase family. SWISS: Q02252 Gene ID: 4329 Database links: Entrez Gene: 4329 Human SwissProt: Q02252 Human
Product Picture	Sample: Lane 1: MCF-7 cell lysates Lane 2: T47D cell lysates Primary: Anti-ALDH6A1 (SLM-51469M) at 1:1000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 59 kD Observed band size: 56 kD Paraformaldehyde-fixed, paraffin embedded ( human LIVER section); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ALDH6A1) Monoclonal Antibody, Unconjugated (SLM-51469M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded ( human colon section); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ALDH6A1) Monoclonal Antibody, Unconjugated (SLM-51469M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining. MCF7 cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (ALDH6A1) monoclonal Antibody, Unconjugated (SLM-51469M) 1:25, 90 minutes at 37°C; followed by a conjugated Goat Anti-Mouse IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.Alexa Fluor® 555 conjugated with Phalloidin(red) was used to stain the cell Cytoplasmic actin .

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