Product Name	LC3
Chinese Name	自噬微管相关蛋白轻链3单克隆抗体
Alias	MLP3A_HUMAN; Microtubule-associated proteins 1A/1B light chain 3A; MAP1LC3A; Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; MAP1A/MAP1B light chain 3 A (MAP1A/MAP1B LC3 A); Microtubule-associated protein 1 light chain 3 alpha; MLP3B_HUMAN; Microtubule-associated proteins 1A/1B light chain 3B; MAP1LC3B; MAP1ALC3; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B (MAP1A/MAP1B LC3 B); Microtubule-associated protein 1 light chain 3 beta;
literatures	Specific References  (2)     |     SLM-51460M has been referenced in 2 publications. [IF=13.281] Jinjin Shi. et al. Photoactivated Self-Disassembly of Multifunctional DNA Nanoflower Enables Amplified Autophagy Suppression for Low-Dose Photodynamic Therapy. 2021 Oct 20  WB ;  Human.   PubMed:34672076 [IF=6.025] Xuliang Zhang. et al. PINK1/Parkin-mediated mitophagy mitigates T-2 toxin-induced nephrotoxicity. FOOD CHEM TOXICOL. 2022 Jun;164:113078  WB ;  Mouse.   PubMed:35489469
Research Area	Tumour  Signal transduction  Apoptosis  transcriptional regulatory factor  Cell differentiation
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	L3G1
React Species	Human, Mouse, Rat,
Applications	WB=1:500-1000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	13kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant protein of human MAP1LC3A/B
Lsotype	IgG1,k
Purification	affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. LC3, a ubiquitin-like modifier protein, is the human homolog of yeast Apg8 and is involved in the formation of autophagosomal vacuoles, called autophagosomes. LC3 is expressed as 3 splice variants (LC3A, LC3B and LC3C), which exhibit different tissue distributions and are processed into cytosolic and autophagosomal membrane-bound forms, termed LC3-I and LC3-II, respectively. A disruption to the autophagic process is now associated with the progression of several cancers, neurodegenerative disorders and cardiac pathologies, where LC3 is widely employed as a marker for autophagy. Function: Probably involved in formation of autophagosomal vacuoles (autophagosomes). Subunit: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Subcellular Location: Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes. Tissue Specificity: Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes. Post-translational modifications: The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II. Similarity: Belongs to the MAP1 LC3 family. SWISS: Q9GZQ8; Q9H492 Gene ID: 81631 Database links: Entrez Gene: 81631 Human SwissProt: Q9GZQ8 Human
Product Picture	Sample: Lane 1: Brain (Mouse) Tissue Lysate Lane 2: Brain (Rat) Tissue Lysate Lane 3: Brain (Human) Tissue Lysate Primary: Anti-LC3 (SLM-51460M) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 13 kD Observed band size: 17 kD Sample: Human Hela cell lysates, which were treated with rapamycin or bafilomycin overnight. Data courtesy of Dr. David Rubinsztein, Cambridge Institute for Medical Research. Primary: Anti-LC3 (SLM-51460M) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 13 kD Observed band size: 13 kD Sample: Lane 1: Y79 (soluble fraction of cell extract) cell lysate Lane 2: 293 transfected with human LC3 (whole cell extract) cell lysate Primary: Anti-LC3 (SLM-51460M) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 13 kD Observed band size: 18/16 kD

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