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Product Name RAB3A Chinese Name Ras癌基因家族Rab3a单克隆抗体 Alias Rab 3A; RAB 3A member RAS oncogene family; Rab3a; RAB3A member RAS oncogene family; RAB3A_HUMAN; RAS associated protein RAB 3A; RAS associated protein RAB3A; Ras related protein Rab 3A; Ras related protein Rab3A; Ras-related protein Rab-3A. Research Area immunology Signal transduction G protein signal Immunogen Species Mouse Clonality Monoclonal Clone NO. 5B7 React Species Mouse, (predicted: Human, Rat, ) Applications WB=1:200-1000 ELISA=1:5000-10000 ICC=1:100-500 IF=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 25kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen Recombinant human RAB3A Lsotype IgG1,k Purification affinity purified by Protein G Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail RAB3A (RAB3A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB3A include Growth Hormone Deficiency, Isolated, Type Ii. Among its related pathways are Innate Immune System and Neurotransmitter Release Cycle. GO annotations related to this gene include GTP binding and protein C-terminus binding. An important paralog of this gene is RAB3C.
Function:
Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
Subunit:
Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A and RPH3AL. Interacts with the exocyst complex through SEC15. Binds SYTL4 and RIMS1. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3 (By similarity).
Subcellular Location:
Cell membrane; Lipid-anchor; Cytoplasmic side (Potential).
Tissue Specificity:
Specifically expressed in brain.
Similarity:
Belongs to the small GTPase superfamily. Rab family.
SWISS:
P20336
Gene ID:
5864
Database links:Entrez Gene: 5864 Human
Entrez Gene: 19339 Mouse
Omim: 179490 Human
SwissProt: P20336 Human
SwissProt: P63011 Mouse
Unigene: 27744 Human
Unigene: 5083 Mouse
Unigene: 44409 Rat
Product Picture Sample:
Cerebellum (Mouse) Lysate at 40 ug
Cerebrum (Mouse) Lysate at 40 ug
Primary: Anti- RAB3A (SLM-51311M) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 25 kD
Observed band size: 25 kD
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