Product Name	LAMP1
Chinese Name	溶酶体相关膜蛋白1（CD107）单克隆抗体
Alias	CD107 antigen like family member A; CD107 antigen-like family member A; CD107a; CD107a antigen; LAMP 1; LAMP-1; LAMP1_HUMAN; LAMPA; LGP120; lgpA; Lysosomal membrane glycoprotein 120KD; Lysosomal Associated Membrane Protein 1; Lysosome associated membrane glycoprotein 1; Lysosome-associated membrane glycoprotein 1; Lysosome-associated membrane glycoprotein 1; Lysosome-associated membrane protein 1;
literatures	Specific References  (1)     |     SLM-51301M has been referenced in 1 publications. [IF=7.464] Lu Zhang. et al. Southern rice black-streaked dwarf virus induces incomplete autophagy for persistence in gut epithelial cells of its vector insect. PLOS PATHOG. 2023 Jan;19(1):e1011134  CoIP ;  Spodoptera frugiperda.   PubMed:36706154
Research Area	Tumour  immunology  Neurobiology  Signal transduction  Stem cells  Cell type markers  The new supersedes the old
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	2C5
React Species	Human,
Applications	WB=1:500-1000 ELISA=1:5000-10000 IF=1:20-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	42kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LAMP1
Lsotype	IgG1,k
Purification	affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation. Function: Presents carbohydrate ligands to selectins. Also mplicated in tumor cell metastasis. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane. Post-translational modifications: O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. Similarity: Belongs to the LAMP family. SWISS: P11279 Gene ID: 3916 Database links: Entrez Gene: 3916 Human Entrez Gene: 16783 Mouse Entrez Gene: 25328 Rat Omim: 153330 Human SwissProt: P11279 Human SwissProt: P11438 Mouse SwissProt: P14562 Rat Unigene: 494419 Human Unigene: 16716 Mouse Unigene: 475822 Mouse Unigene: 40177 Rat
Product Picture	Sample: Lane 1: Human HT1080 cell lysates Lane 2: Human Hela cell lysates Lane 3: Human U937 cell lysates Primary: Anti-LAMP1 (SLM-51301M) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 42 kDa Observed band size: 90-120 kDa

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