Product Name	CYP1A1
Chinese Name	细胞色素P450 1A1单克隆抗体
Alias	Cytochrome p450 1A1; AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX; AHH; AHRR; Aryl hydrocarbon hydroxylase; CYP 1; CYP1A1; CYPIA1; Cytochrome P1-450; Flavoprotein-linked monooxygenase; Microsomal monooxygenase; P1 450; P450 C; P450 form 6; P450 P1; Xenobiotic monooxygenase.
Research Area	Cell biology  immunology  Synthesis and Degradation
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	10G3
React Species	Human,  (predicted: Mouse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	58kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CYP1A1: 377-405/512
Lsotype	IgG1
Purification	affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The Cytochrome P450 (P450) superfamily of enzymes is one of three enzyme systems which metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several cofactors such as nicotinamide adenine dinucleotide phosphate (NADPH) and P450 reductase. There are over 200 known genes which encode P450s. Epoxygenases are those P450s which metabolize AA to epoxyeicosatrienoic acid (EETs) and omega hydroxylases are those P450s which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE). As well as fatty acid metabolism, P450s also metabolize many drugs and toxins. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin. Function: Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. Subcellular Location: Cytochrome P450 1A1: Cytoplasm. Cytochrome P450MT2A: Endoplasmic reticulum membrane. Mitochondrion membrane. Microsome membrane. Cytochrome P450MT2B: Endoplasmic reticulum. Mitochondrion. Tissue Specificity: Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus. Down-regulated malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary. Similarity: Belongs to the cytochrome P450 family. SWISS: A9YTQ3 Gene ID: 57491 Database links: Entrez Gene: 57491 Human Entrez Gene: 11624 Mouse Entrez Gene: 498999 Rat Omim: 606517 Human SwissProt: A9YTQ3 Human SwissProt: Q3U1U7 Mouse SwissProt: Q75NT5 Rat Unigene: 50823 Human Unigene: 290446 Mouse Unigene: 145524 Rat
Product Picture	Sample: A549(Human) Cell Lysate at 30 ug SiHa(Human) Cell Lysate at 30 ug Primary: Anti-CYP1A1 (SLM-51210M) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 58 kD Observed band size: 58 kD

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