Product Name	GFAP
Chinese Name	胶质纤维酸性蛋白单克隆抗体
Alias	Astrocyte; FLJ45472; GFAP; Glial Fibrillary Acidic Protein; Intermediate filament protein; GFAP_HUMAN.
literatures	Specific References  (1)     |     SLM-51047M has been referenced in 1 publications. [IF=2.23] Li et al. Melatonin lowers edema after spinal cord injury. (2014) Neural.Regen.Res. 9:2205-10  IHC ;  Rat.   PubMed:25657743
Research Area	Tumour  Cell biology  immunology  Neurobiology  Signal transduction  Stem cells  Cell adhesion molecule  Cytoskeleton
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	5C4
React Species	(predicted: Human, )
Applications	WB=1:100-500 IHC-P=1:100-500 IHC-F=1:20-100 ICC=1:20-100 IF=1:20-100 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	48kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human GFAP
Lsotype	IgG2b
Purification	affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] Function: GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. Subunit: Interacts with SYNM. Isoform 3 interacts with PSEN1 (via N-terminus). Subcellular Location: Cytoplasm. Note=Associated with intermediate filaments. Tissue Specificity: Expressed in cells lacking fibronectin. Post-translational modifications: Phosphorylated by PKN1. DISEASE: Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course. Similarity: Belongs to the intermediate filament family. SWISS: P14136 Gene ID: 2670 Database links: Entrez Gene: 281189 Cow Entrez Gene: 2670 Human Entrez Gene: 14580 Mouse Entrez Gene: 24387 Rat Omim: 137780 Human SwissProt: Q28115 Cow SwissProt: P14136 Human SwissProt: P03995 Mouse

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