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Product Name MAPK15/ERK8 Chinese Name 丝裂原活化蛋白激酶15单克隆抗体 Alias ERK-7; ERK-8; ERK7; ERK8; Extracellular regulated kinase 8 delta; Extracellular signal regulated kinase 8; Extracellular signal-regulated kinase 7; Extracellular signal-regulated kinase 8; MAP kinase 15; MAPK 15; Mapk15; Mitogen activated protein kinase 15; Mitogen-activated protein kinase 15; MK15_HUMAN Research Area Cell biology Signal transduction Kinases and Phosphatases Immunogen Species Mouse Clonality Monoclonal Clone NO. 7C2 React Species (predicted: Human, ) Applications WB=1:100-500 IHC-P=1:100-500 IHC-F=1:20-100 ICC=1:20-100 IF=1:20-100 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 60kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MAPK15/ERK8 Lsotype IgG1 Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail MAPK15 is a 544 amino acid protein that belongs to the CMGC Ser/Thr protein kinase family (MAP kinase subfamily). MAP kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation and apoptosis. MAPK15 functions as a catalytic kinase using ATP to produce ADP and a phosphoprotein. A TXY motif, containing one threonine and one tyrosine residue, activates the MAP kinases upon phosphorylation. MAPK15 is a ubiquitously expressed protein with highest expression found in lung and kidney.
Function:
In vitro, phosphorylates MBP.
Tissue Specificity:
Widely expressed with a maximal expression in lung and kidney.
Post-translational modifications:
Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme. Autophosphorylated on threonine and tyrosine residues in vitro.
Ubiquitinated. Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase.
Similarity:
Belongs to the protein kinase superfamily.
CMGC Ser/Thr protein kinase family.
MAP kinase subfamily.
Contains 1 protein kinase domain.
SWISS:
Q8TD08
Gene ID:
225689
Database links:Entrez Gene: 225689 Human
SwissProt: Q8TD08 Human
Unigene: 493169 Human
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