Product Name	phospho-FXYD1 (Ser88)
Chinese Name	磷酸化FXYD1单克隆抗体
Alias	FXYD domain containing ion transport regulator 1; Phospholemman; PLM; PLM_MOUSE; PLM_HUMAN;
Research Area	Tumour  immunology  Neurobiology  Channel protein  The new supersedes the old
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	10E2
React Species	(predicted: Mouse, )
Applications	WB=1:500-1000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	10kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthesised phosphopeptide derived from mouse FXYD1 around the phosphorylation site of Ser88: RL(p-S)SR
Lsotype	IgG1
Purification	affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	PLM (FXYD1)is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. PLM may be phosphorylated by several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Function: May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining. Very low levels in kidney, colon and small intestine without mucosa, prostate without endothelial lining, spleen, and testis. Post-translational modifications: Major plasma membrane substrate for cAMP-dependent protein kinase (PK-A) and protein kinase C (PK-C) in several different tissues. Phosphorylated in response to insulin and adrenergic stimulation. May be phosphorylated by DMPK (By similarity). Palmitoylation increases half-life and stability, it is enhanced upon phosphorylation at Ser-88 by PKA. Similarity: Belongs to the FXYD family. SWISS: Q9Z239 Gene ID: 56188 Database links: Entrez Gene: 476487 Dog Entrez Gene: 5348 Human Entrez Gene: 56188 Mouse Entrez Gene: 58971 Rat Omim: 602359 Human SwissProt: P56513 Dog SwissProt: O00168 Human SwissProt: Q9Z239 Mouse SwissProt: O08589 Rat Unigene: 442498 Human

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