Product Name	Human PD-1
Chinese Name	人程序性死亡1单克隆抗体
Alias	Programmed cell death protein 1; CD279; CD279 antigen; hPD 1; hPD-1; hSLE1; PD 1; PD1; PDCD 1; PDCD1; PDCD1_HUMAN; Programmed cell death 1; Protein PD 1; Protein PD-1; SLEB2; Systemic lupus erythematosus susceptibility 2.
Research Area	Tumour  Cell biology  immunology  Apoptosis
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	2B7
React Species	Human,
Applications	WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1:100  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	19.8kDa
Cellular localization	The cell membrane
Form	Liquid
immunogen	Recombinant Human PD-1 Protein: 24-170/170
Lsotype	IgG2b
Purification	affinity purified by Protein A
Buffer Solution	0.01M PBS(pH7.4)
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020] Function: Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors. Subunit: Monomer. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Ta,Ba,Ma,Thy DISEASE: Systemic lupus erythematosus 2 (SLEB2) [MIM:605218]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269|PubMed:12402038}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain. SWISS: Q15116 Gene ID: 5133 Database links: Entrez Gene: 5133 Human Entrez Gene: 18566 Mouse Entrez Gene: 301626 Rat Omim: 600244 Human SwissProt: Q15116 Human SwissProt: Q02242 Mouse Unigene: 158297 Human Unigene: 5024 Mouse Unigene: 105023 Rat
Product Picture	Sample: Lane 1: Human PD-1 Protein at 100ng Primary: Mouse Anti-Human PD-1 Protein Antibody at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 19.8kD Observed band size: 27-44kD Blank control:MCF7. Primary Antibody (green line): Mouse Anti-PD-1 antibody (SLM-41654M) Dilution: 1：100; Secondary Antibody : Goat anti-mouse IgG-FITC Dilution: 0.5ug/Test. Protocol The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.

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