Product Name	Thyroid peroxidase
Chinese Name	甲状腺过氧化物酶抗体
Alias	MSA; PERT_HUMAN; TDH2A; Thyroid microsomal antigen; Thyroid peroxidase; Thyroperoxidase; TPO; TPX.
Research Area	Tumour  Cell biology  immunology  Neurobiology  Signal transduction  Growth factors and hormones  Kinases and Phosphatases  Endocrinopathy
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	6C3
React Species	Human,
Applications	IHC-P=1:200-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	101kDa
Cellular localization	The cell membrane Extracellular matrix
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Thyroid peroxidase
Lsotype	IgG2b,k
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]. Function: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). Subunit: Interacts with DUOX1, DUOX2 and CYBA. Subcellular Location: Membrane; Single-pass type I membrane protein. Isoform 3: Cell surface. Post-translational modifications: Glycosylated. Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface. Cleaved in its N-terminal part. DISEASE: Note=An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease. Defects in TPO are the cause of thyroid dyshormonogenesis 2A (TDH2A) [MIM:274500]. A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. Similarity: Belongs to the peroxidase family. XPO subfamily. Contains 1 EGF-like domain. Contains 1 Sushi (CCP/SCR) domain. SWISS: P35419 Gene ID: 7173 Database links: Entrez Gene: 7173 Human Omim: 606765 Human SwissProt: P07202 Human Unigene: 467554 Human 甲状腺过氧化物酶TPO是一种含铁卟啉的血红蛋白类物质，位于甲状腺epithelial cells的顶端The cell membrane上。 TPO主要的生物学作用是使碘活化，酪氨酸碘化和促进碘化酪氨酸的耦联，在甲状腺激素合成过程中起着关键作用-是甲状腺激素合成过程中的关键酶.
Product Picture	Paraformaldehyde-fixed, paraffin embedded (human thyroid gland); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (hyroid peroxidase) Monoclonal Antibody, Unconjugated (SLM-34081M ) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.

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