Product Name	ADGRE1 (F4/80)
Chinese Name	小鼠抗表皮生长因子样激素受体1（EMR1）单克隆抗体
Alias	F4/80 (mouse); Adhesion G protein-coupled receptor E1; Cell surface glycoprotein EMR1; Cell surface glycoprotein F4/80; DD7A5 7; Egf like module containing mucin like hormone receptor like 1; Egf like module containing mucin like hormone receptor like sequence 1; EGF like module receptor 1; EGF TM7; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EGFTM7; EMR 1; EMR1; EMR-1; EMR1 hormone receptor; EMR1_HUMAN; AGRE1_HUMAN; Gpf480; Ly71; Lymphocyte antigen 71; TM7LN3.
literatures	Specific References  (8)     |     SLM-34028M has been referenced in 8 publications. [IF=14.593] Jingxin Hou. et al. LIFU-responsive nanomedicine enables acoustic droplet vaporization-induced apoptosis of macrophages for stabilizing vulnerable atherosclerotic plaques. Bioact Mater. 2022 Mar;:  IHC ;  Mouse.   PubMed:35386311 [IF=9.434] Xihong Zhou. et al. Intestinal accumulation of microbiota-produced succinate caused by loss of microRNAs leads to diarrhea in weanling piglets. GUT MICROBES. 2022 Jun 26  IHC, WB ;  Pig, Mouse.   PubMed:35758253 [IF=8.44] Chen Xin-Sen. et al. Angiotensin-(1–7) ameliorates sepsis-induced cardiomyopathy by alleviating inflammatory response and mitochondrial damage through the NF-κB and MAPK pathways. J TRANSL MED. 2023 Dec;21(1):1-21  IF ;  Mouse.   PubMed:36593471 [IF=7.571] Xiao-Dan Li. et al. Fabricating biodegradable calcium phosphate/calcium sulfate cement reinforced with cellulose: in vitro and in vivo studies. J MATER CHEM B. 2022 Nov;:  IF ;  Mouse.   PubMed:36440610 [IF=7.348] Shaodan Ma. et al. Robust drug bioavailability and safety for rheumatoid arthritis therapy using D-amino acids-based supramolecular hydrogels. MATER TODAY BIO. 2022 May;:100296  IF ;  Mouse.   PubMed:10.1016/j.mtbio.2022.100296 [IF=6.208] Longcong Dong. et al. Shared Genes of PPARG and NOS2 in Alzheimer’s Disease and Ulcerative Colitis Drive Macrophages and Microglia Polarization: Evidence from Bioinformatics Analysis and Following Validation. INT J MOL SCI. 2023 Jan;24(6):5651  IF ;  Mouse.   PubMed:36982725 [IF=5.763] You Shuang. et al. Recombinant humanized collagen remodels endometrial immune microenvironment of chronic endometritis through macrophage immunomodulation. REGEN BIOMATER. 2023 Apr;:  IF ;  Rat.   PubMed:37122820 [IF=5.195] Ming-Hui Li. et al. Fufang Zhenzhu Tiaozhi capsule ameliorates hyperuricemic nephropathy by inhibition of PI3K/AKT/NF-κB pathway. J ETHNOPHARMACOL. 2022 Aug;:115644  IHC ;  Mouse.   PubMed:35987412
Research Area	Cell biology  immunology  Growth factors and hormones  G protein-coupled receptor  glycoprotein
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	3D4
React Species	Human,  (predicted: Mouse, Rat, )
Applications	WB=1:100-1000 IP=1:20-100 IHC-P=1:100-500 IF=1:50-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	95kDa
Detection molecular weight	160 kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	200ug/ml
immunogen	KLH conjugated synthetic peptide derived from mouse F4/80
Lsotype	IgG
Purification	affinity purified by Protein G
Buffer Solution	0.01M PBS(pH7.4) with 0.1% BSA, 0.03% Proclin300.
Storage	Shipped at 4℃. Store at 2-8℃ for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The epidermal growth factor (EGF)-TM7 family constitutes a group of class B G-protein coupled receptors, which includes CD97, EMR1 (EGF-like molecule containing mucin-like hormone receptor 1, designated F4/80 in mouse), EMR2, EMR3, FIRE, and ETL (1–3). These family members are characterized by an extended extracellular region with several N-terminal EGF domains, and are predominantly expressed on cells of the immune system (1–3). The EGF-TM7 protein family are encoded by a gene cluster on human chromosome 19p13 (1,3,4). The F4/80 molecule is solely expressed on the surface of macrophages and serves as a marker for mature macrophage tissues, including Kupffer cells in liver, splenic red pulp macrophages, brain microglia, gut lamina propria, and Langerhans cells in the skin (1). F4/80/EMR1 undergoes extensive N-linked glycosylation as well as some O-linked glycosylation (5,6). The function of F4/80/EMR1 is unclear, but it is speculated to be involved in macrophage adhesion events, cell migration, or as a G-protein coupled signaling component of macrophages. Function: Could be involved in cell-cell interactions. Subunit: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 6 EGF-like domains. Contains 1 GPS domain. Subcellular Location: Cell membrane. Tissue Specificity: Wide expression; increased levels in peripheral blood mononuclear cells. Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 6 EGF-like domains. Contains 1 GPS domain. SWISS: Q14246 Gene ID: 2015 Database links: Entrez Gene: 2015 Human Entrez Gene: 13733 Mouse Omim: 600493 Human SwissProt: Q14246 Human SwissProt: Q61549 Mouse Unigene: 2375 Human Unigene: 2254 Mouse

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