Product Name	ERCC1
Chinese Name	DNA切除修复蛋白1单克隆抗体
Alias	Excision Repair Cross Complementing 1; DNA excision repair protein ERCC-1; COFS4; UV20; DNA excision repair protein ERCC1; ERCC 1; Excision Repair Cross Complementing Rodent Repair Deficiency Complementation Group 1; Excision repair protein; UV 20; UV20;DNA excision repair protein ERCC-1.
Research Area	Tumour  Cell biology  immunology
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	2A4
React Species	Human,
Applications	WB=1:500-2000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	36kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ERCC1
Lsotype	IgG1
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009] Subunit: Heterodimer composed of ERCC1 and XPF/ERRC4. Subcellular Location: Nucleus. Similarity: Belongs to the ERCC1/RAD10/SWI10 family. SWISS: P07992 Gene ID: 2067 Database links: Entrez Gene: 2067 Human Entrez Gene: 13870 Mouse Entrez Gene: 292673 Rat Omim: 126380 Human SwissProt: P07992 Human SwissProt: P07903 Mouse Unigene: 435981 Human Unigene: 280913 Mouse Unigene: 7320 Rat
Product Picture	Sample: U87MG(Human) Cell Lysate at 30 ug Primary: Anti- ERCC1 (SLM-33445M) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 36 kD Observed band size: 38 kD

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