Product Name	Alpha-actinin-1
Chinese Name	α-辅肌动蛋白1单克隆抗体
Alias	ACTN 1; ACTN1_HUMAN; Alpha Actinin 1; Alpha actinin cytoskeletal isoform; Alpha-actinin cytoskeletal isoform; Alpha-actinin-1; FLJ40884; FLJ54432; Actinin Alpha 1; F-Actin Cross-Linking Protein; Non-Muscle Alpha-Actinin-1; Actinin, Alpha 1; Actinin 1 Smooth Muscle; BDPLT15;
literatures	Specific References  (1)     |     SLM-33272M has been referenced in 1 publications. [IF=5.5] Chen, Yejia. et al. Complement C5a induces the generation of neutrophil extracellular traps by inhibiting mitochondrial STAT3 to promote the development of arterial thrombosis. THROMB J. 2022 Dec;20(1):1-14  WB ;  Human.   PubMed:35488279
Research Area	Cell biology  Developmental biology  Cytoskeleton
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	6A10
React Species	(predicted: Human, Mouse, Rat, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:500-1000 ICC=1:100-500 IF=1:500-1000 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	103kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human Alpha-actinin-1 protein 1-205/894 (C-6x His-Tag)
Lsotype	IgG
Purification	affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Subunit: Homodimer; antiparallel. Interacts with DDN, MYOZ2, PDLIM2, TTID and LPP. Interacts with PSD. Interacts with MICALL2 (By similarity). Interacts with DNM2 and CTTN (By similarity). Subcellular Location: Cytoplasm > cytoskeleton. Cytoplasm > myofibril > sarcomere > Z line. Cell membrane. Cell junction. Cell projection › ruffle. Similarity: Belongs to the alpha-actinin family. Contains 1 actin-binding domain. Contains 2 CH (calponin-homology) domains. Contains 2 EF-hand domains. Contains 4 spectrin repeats. SWISS: P12814 Gene ID: 87 Database links: Entrez Gene: 87 Human Entrez Gene: 109711 Mouse Entrez Gene: 81634 Rat Omim: 102575 Human SwissProt: P12814 Human SwissProt: Q7TPR4 Mouse SwissProt: Q9Z1P2 Rat Unigene: 509765 Human Unigene: 253564 Mouse Unigene: 403477 Mouse Unigene: 6401 Rat

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