TEL: +86 571 56623320 EMAIL: [email protected]
Product Name Transferrin Chinese Name 转铁蛋白单克隆抗体 Alias Apotransferrin; TRF; eta 1 metal binding globulin; DKFZp781D0156; PRO1400; PRO1557; PRO2086; Serotransferrin precursor; Siderophilin; TF; TRFE_HUMAN; Beta-1 metal-binding globulin; Serotransferrin. Research Area Cardiovascular Immunogen Species Mouse Clonality Monoclonal Clone NO. 5A4 React Species Human, Applications WB=1:500-1000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 77kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen Full length native Transferrin protein purified from human plasma Lsotype IgG Purification affinity purified by Protein G Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009].
Function:
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
Subunit:
Monomer.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed by the liver and secreted in plasma.
DISEASE:
Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.
Similarity:
Belongs to the transferrin family.
Contains 2 transferrin-like domains.
SWISS:
P02787
Gene ID:
7018
Database links:Entrez Gene: 7018 Human
Entrez Gene: 22041 Mouse
Omim: 190000 Human
SwissProt: P02787 Human
SwissProt: Q921I1 Mouse
Unigene: 518267 Human
Unigene: 37214 Mouse
Unigene: 91296 Rat
Product Picture
Scan Wechat Qrcode