Product Name	beta II Tubulin / Tubulin beta 2
Chinese Name	微管蛋白beta 2单克隆抗体
Alias	Class IIa beta tubulin; dJ40E16.7; M(beta)2; TBB2A_HUMAN; TUBB; TUBB2; Tubb2a; Tubulin beta 2; Tubulin beta 2A; Tubulin beta 2A class IIa; Tubulin beta polypeptide 2; Tubulin beta polypeptide; Tubulin beta-2A chain.  β II tubulin; β-II tubulin; β II-tubulin; βII tubulin; βII-tubulin;
Research Area	Cell biology  immunology  Neurobiology  Cytoskeleton
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	3G9
React Species	(predicted: Human, Mouse, Rat, )
Applications	WB=1:500-5000 IP=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	50kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human beta II Tubulin
Lsotype	IgG
Purification	affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Microtubules, key participants in processes such as mitosis and intracellular transport, are composed of heterodimers of alpha- and beta-tubulins. The protein encoded by this gene is a beta-tubulin. Defects in this gene are associated with complex cortical dysplasia with other brain malformations-5. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2015] Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Subunit: Interacts with ZNRF1 (By similarity). Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity (By similarity). Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Subcellular Location: Cytoplasm; cytoskeleton Tissue Specificity: High expression in brain, where it represents 30% of all beta-tubulins. Post-translational modifications: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable). Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules. Similarity: Belongs to the tubulin family. SWISS: Q13885 Gene ID: 7280 Database links: Entrez Gene: 7280 Human Entrez Gene: 22151 Mouse Entrez Gene: 498736 Rat SwissProt: Q13885 Human SwissProt: Q7TMM9 Mouse SwissProt: P85108 Rat Unigene: 654543 Human Unigene: 422827 Mouse Unigene: 225893 Rat

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