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Product Name CD41/ITGA2B Chinese Name 血小板膜glycoproteinⅡb(CD41)单克隆抗体 Alias platelet glycoprotein IIb of IIb/IIIa complex; Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); GPIIb; GTA; HPA3; CD 41; CD41 antigen; CD41a; CD41b; GP2b; GPalpha IIb; GPalphaIIb; Integrin alpha IIb; Integrin alpha IIb precursor; ITGA 2B; Integrin alpha 2b; ITGAB; Platelet fibrinogen receptor alpha; Platelet fibrinogen receptor alpha subunit; Platelet glycoprotein IIb of IIb/IIIa complex; Platelet membrane glycoprotein IIb; Platelet specific antigen bak; ITA2B_HUMAN. Research Area Tumour Cell biology immunology Signal transduction Cell adhesion molecule Immunogen Species Mouse Clonality Monoclonal Clone NO. 9B10 React Species Human, Applications WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1ug/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 125kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human ITGA2B Lsotype IgG Purification affinity purified by Protein G Buffer Solution 0.01M PBS(pH7.4) with 0.1%Proclin300 Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016]
Function:
Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
Subcellular Location:
Membrane.
DISEASE:
Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.
Similarity:
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
SWISS:
P08514
Gene ID:
3674
Database links:Entrez Gene: 3674 Human
Entrez Gene: 16399 Mouse
Omim: 607759 Human
SwissProt: P08514 Human
SwissProt: Q9QUM0 Mouse
Unigene: 411312 Human
Unigene: 26646 Mouse
Unigene: 128177 Rat
Product Picture Sample:
Lane 1: HL60 (Human) Cell Lysate at 30 ug
Lane 2: Raji (Human) Cell Lysate at 30 ug
Primary:
Anti-CD41/Integrin alpha 2b (SLM-33112M) at 1/1000 dilution
Anti-beta-Actin (SL0061R) at 1/2000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 125 kD
Observed band size: 125 kD
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