Product Name	human CD273 (B7-DC, PD-L2)
Chinese Name	小鼠抗人CD273 (B7-DC, PD-L2)单克隆抗体
Alias	PD L2; PD-L2; PD1L2_HUMAN; B7 dendritic cell molecule; B7-DC; B7DC; bA574F11.2; Btdc; Butyrophilin B7 DC; Butyrophilin B7-DC; Butyrophilin B7DC; CD 273; CD273; CD273 antigen; MGC142238; MGC142240; PD 1 ligand 2; PD-1 ligand 2; PD1 ligand 2; PDCD 1 ligand 2; PDCD1 ligand 2; PDCD1L2; PDL 2; PDL2; Programmed cell death 1 ligand 2; Programmed death ligand 2.
Research Area	immunology
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	2C10
React Species	(predicted: Human, )
Applications	IHC-P=1:100-500 IHC-F=1:20-200 Flow-Cyt= ICC=1:20-200 IF=1:20-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	29kDa
Detection molecular weight	42
Cellular localization	The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CD273 (B7-DC)
Lsotype	Mouse IgG1
Purification	Affinity purified by Protein G
Buffer Solution	0.01M TBS(pH=7.4)
Storage	Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Involved in negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; and negative regulation of interleukin-10 production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of pulmonary tuberculosis. [provided by Alliance of Genome Resources, Nov 2021] Function: Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity). Subunit: Interacts with PDCD1. Subcellular Location: Isoform 3: Secreted (Probable). Isoform 2: Endomembrane system; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus. Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. SWISS: Q9BQ51 Gene ID: 80380 Database links: Entrez Gene: 80380 Human Omim: 605723 Human SwissProt: Q9BQ51 Human Unigene: 532279 Human Unigene: 617872 Human

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