Mouse Anti-human CD20 antibody
CD20_HUMAN; B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; MS4A1; MS4A2; B1; CVID5; LEU-16; S7.
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Product Name human CD20 Chinese Name 小鼠抗人CD20单克隆抗体 Alias CD20_HUMAN; B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; MS4A1; MS4A2; B1; CVID5; LEU-16; S7. Research Area Tumour immunology Stem cells Cell Surface Molecule b-lymphocyte Immunogen Species Mouse Clonality Monoclonal Clone NO. HI20a React Species Human, Applications Flow-Cyt=2ul/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 33kDa Detection molecular weight 33-37 Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CD20 Lsotype Mouse IgG2a Purification Affinity purified by Protein G Buffer Solution 0.01M TBS(pH=7.4) Storage Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
Function:
This protein may be involved in the regulation of B-cell activation and proliferation
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed on B-cells.
Post-translational modifications:
Phosphorylated. Might be functionally regulated by protein kinase(s).
DISEASE:
Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Similarity:
Belongs to the MS4A family.
SWISS:
P11836
Gene ID:
931
Database links:Entrez Gene: 931 Human
Omim: 112210 Human
SwissProt: P11836 Human
Unigene: 712553 Human
Product Picture 
Blank control:whole blood.
Primary Antibody (green line): Mouse Anti-CD20 antibody (SLM-30098M)
Dilution: 2ul/Test;
Secondary Antibody : Goat anti-Mouse IgG-FITC
Dilution: 0.5ug/Test.
Protocol
Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
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