Product Name	human CD8
Chinese Name	小鼠抗人CD8单克隆抗体
Alias	CD8 antigen, alpha polypeptide (p32); CD8a; CD8a antigen; CD8a molecule; CD8A_MOUSE; CD8A_HUMAN; Leu2; Leu2 T lymphocyte antigen; MAL; OKT8 T cell antigen; p32; T cell antigen Leu2; T cell co receptor; T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2; T8 T cell antigen.
literatures	Specific References  (2)     |     SLM-30094M has been referenced in 2 publications. [IF=9.918] Daijun Zhou. et al. An injectable miR181a-IFI6 nanoparticles promote high-quality healing of radiation-induced skin injury. MATER TODAY ADV. 2022 Aug;15:100267  FC ;  Human.   PubMed:10.1016/j.mtadv.2022.100267 [IF=9.776] Yingli Wang. et al. Paclitaxel derivative-based liposomal nanoplatform for potentiated chemo-immunotherapy. J Control Release. 2022 Jan;341:812  IF ;  Mouse.   PubMed:34953979
Research Area	Cell biology  immunology  Cell Surface Molecule  t-lymphocyte
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	HIT8a
React Species	Human,
Applications	Flow-Cyt=5ul/Test  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	27kDa
Detection molecular weight	32-34
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human CD8
Lsotype	Mouse IgG1, k
Purification	Affinity purified by Protein G
Buffer Solution	0.01M TBS(pH=7.4)
Storage	Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. [provided by RefSeq, May 2020] Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Most prominently found in the gastrointestinal tract, skin, lung, and brain but not in liver. Similarity: Belongs to the PMP-22/EMP/MP20 family. SWISS: P01732 Gene ID: 925 Database links: Entrez Gene: 925 Human Entrez Gene: 926 Human Entrez Gene: 12525 Mouse Entrez Gene: 12526 Mouse Omim: 186910 Human SwissProt: P01732 Human SwissProt: P10966 Human SwissProt: P01731 Mouse SwissProt: P10300 Mouse Unigene: 405667 Human Unigene: 85258 Human Unigene: 1858 Mouse Unigene: 333148 Mouse

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