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Product Name human CD34-FITC Chinese Name FITC标记人CD34单克隆抗体 Alias CD34 antigen; CD34 molecule; Cluster designation 34; Hematopoietic progenitor cell antigen CD34; HPCA1; CD34_HUMAN. FITC anti-human CD34; literatures Specific References (1) | SLM-30079M-FITC has been referenced in 1 publications.[IF=5.714] Aimaiti Yasen. et al. Exosomes derived from TGF-β1-pretreated mesenchymal stem cells alleviate biliary ischemia–reperfusion injury through Jagged1/Notch1/SOX9 pathway. INT IMMUNOPHARMACOL. 2023 Jun;119:110253 FCM ; Rat.Research Area Tumour Cardiovascular immunology Neurobiology Stem cells Cell Surface Molecule Cell type markers vascular endothelial cell endothelial cells Immunogen Species Mouse Clonality Monoclonal Clone NO. 4H11 React Species Human, Applications Flow-Cyt=20ul/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 39kDa Cellular localization The cell membrane Form Liquid Lsotype IgG1 Purification affinity purified by Protein G Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.
Function:
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.
Post-translational modifications:
Highly glycosylated.
Phosphorylated on serine residues by PKC.
Similarity:
Belongs to the CD34 family.
SWISS:
P28906
Gene ID:
947
Database links:Entrez Gene: 947 Human
Omim: 142230 Human
SwissProt: P28906 Human
Unigene: 374990 Human
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