Product Name	human CD14
Chinese Name	小鼠抗人CD14单克隆抗体
Alias	Monocyte Differentiation Antigen 14; CD14 antigen; CD14 molecule; Lipopolysaccharide receptor; LPSR; Monocyte differentiation antigen CD14; Myeloid cell specific leucine rich glycoprotein; CD14_HUMAN; Myeloid cell-specific leucine-rich glycoprotein.
Research Area	Cell biology  immunology  Stem cells  Cell Surface Molecule  Cell type markers  lymphocyte
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	14F4
React Species	Human,
Applications	Flow-Cyt=1ul/Test  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	35/40kDa
Detection molecular weight	53-55
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
Lsotype	Mouse IgG1, k
Purification	Affinity purified by Protein G
Buffer Solution	0.01M TBS(pH=7.4)
Storage	Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010] Function: Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules. Subunit: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Similarity: Contains 11 LRR (leucine-rich) repeats. SWISS: P08571 Gene ID: 929 Database links: Entrez Gene: 929 Human Entrez Gene: 12475 Mouse Omim: 158120 Human SwissProt: P08571 Human Unigene: 163867 Human CD14又称内毒素受体，属细胞表面glycoprotein家族成员之一。在机体免疫、防御系统引起的一系列反应中介导细胞识别LPS并引起细胞酪氨酸磷酸化、核因子NF-κB转位、触发cell factor释放和氧自由基产生。CD14在cell factor产生的调控方面起重要作用,因而对于CD14结构、功能及其临床意义的研究日益受到重视。
Product Picture	Blank control:whole blood. Primary Antibody (green line): Mouse Anti-CD14 antibody (SLM-30074M) Dilution: 1ul/Test; Secondary Antibody : Goat anti-mouse IgG-FITC Dilution: 0.5ug/Test. Protocol Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.

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