Product Name	human CD5-PE
Chinese Name	PE标记人CD5单克隆抗体
Alias	T-cell surface glycoprotein CD5; Lymphocyte antigen 1; Ly-1; Lyt-1; CD5; CD5 antigen; CD 5; CD5 molecule; CD5 antigen (p56 62); CD5_HUMAN; LEU 1; LEU1; Ly12; LyA; Lymphocyte Antigen CD5; Lymphocyte antigen T1/Leu 1; Lymphocyte antigen T1/Leu-1; Lymphocyte glycoprotein T1/Leu1; OTTHUMP00000236973; p56 62; T1.  PE anti-human CD5;
Research Area	Cell biology  Stem cells  Cell Surface Molecule
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	HISM2
React Species	Human,
Applications	Flow-Cyt=20ul/Test  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	55kDa
Cellular localization	The cell membrane
Form	Liquid
Lsotype	IgG1
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] Function: May act as a receptor in regulating T-cell proliferation. Subunit: Interacts with CD72/LYB-2. Interacts with PTPN6/SHP-1. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Post-translational modifications: Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1. Similarity: Contains 3 SRCR domains. SWISS: P06127 Gene ID: 921 Database links: Entrez Gene: 921 Human Omim: 153340 Human SwissProt: P06127 Human Unigene: 58685 Human
Product Picture	Flow cytometry staining of normal human peripheral blood cells with CD5/PE(SLM-30067M-PE)(Red histogram) or Mouse IgG1 Isotype Control (PE Conjugate)(C03-11002 )(Blue histogram) . Total cells were used for analysis.

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