Product Name	Cecropin-A
Chinese Name	杀菌肽/天蚕抗菌肽单克隆抗体
Alias	CECA_HYACE; Cecropin-C; Cecropin;   抗菌肽;
Research Area	immunology
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	1D8
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	4kDa
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from Hyalophora cecropia: 1-37/41
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	No data available. Function: Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria. Subcellular Location: Secreted. Post-translational modifications: A protein with the same sequence as cecropin A, but lacking the carboxyl blocking group, has been isolated and called cecropin C (PubMed:7140755). Similarity: Belongs to the cecropin family. SWISS: N/A Gene ID: N/A Database links:     天蚕素(cecropins)是第一个被发现的动物抗菌肽，1980年，由Boman等从天蚕蛹中分离得到。该类多肽抗生素一般含有37～39个氨基酸残基，不含半胱氨酸，其N端区域具有强碱性，可形成近乎完美的双亲螺旋结构，而在C端区域可形成疏水螺旋，两者之间有甘氨酸和脯氨酸形成的铰链区，多数多肽的C端被酰胺化，酰胺化对其抗菌活性具有重要作用。天蚕素(cecropins)对革兰氏阳性菌、部分革兰氏阴性菌具有很强的杀伤力，而对真菌和真核细胞没有毒性。目前研究认为，抗菌肽是最具潜力的抗生素替代品之一。而天蚕素又是目前研究比较清楚的抗菌肽。 天蚕素抗菌肽利用N端所带的正电荷与原核细胞的The cell membrane磷脂双分子层密集的负电荷静电相吸，C端柔性的插入疏水区，在两亲性α-螺旋作用下，在原核The cell membrane上形成4nm的离子通道，离子通道的形成改变了The cell membrane内外的渗透压，The cell membrane内物质大量外渗，致细菌细胞死亡，起到杀菌作用。天蚕素抗菌肽对细菌、病毒、念珠菌、原虫、癌细胞具有广谱的活性，能抑制革兰氏阳性和阴性球菌和杆菌，如绿脓杆菌、大肠杆菌、伤寒杆菌、痢疾杆菌、布氏杆菌、金黄色葡萄球菌、溶血性链球菌等等，并对感染Botany的多种病原菌也有明显的杀菌作用。另外，天蚕素抗菌肽对高度耐药的伤寒杆菌、耐药性金葡菌同样敏感，对感冒、疤疹病毒能抑制其繁殖，对疟原虫、痢疾阿米巴均有效

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