Product Name	HCG Beta(4H7)
Chinese Name	人绒毛膜促性腺激素β亚基/β-HCG单克隆抗体
Alias	β-HCG; HCG-Beta; Beta-HCG; Beta HCG; CGB3_HUMAN; Choriogonadotropin subunit beta 3; CGB3; CGB; CGB5; CGB8; Choriogonadotropin subunit beta (CG-beta); Chorionic gonadotropin chain beta; HCG; hCGB; CG-beta;   βHCG; β HCG.
Research Area	immunology
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	4H7
React Species	Human,
Applications	ELISA=1:5000-100000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	16kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	HCG Beta protein
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M PBS(pH7.4) with 0.03% Proclin300
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB1 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 155 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008] Function: Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific hCGb proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8). The CGB gene first arose in the common ancestor of the anthropoid primates. Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin. Subcellular Location: Secreted. Tissue Specificity: Placenta. Similarity: Belongs to the glycoprotein hormones subunit beta family. SWISS: P0DN86 Gene ID: 1082 Database links: Entrez Gene: 1082 Human Entrez Gene: 93659 Human Entrez Gene: 94027 Human Entrez Gene: 94115 Human Omim: 118860 Human SwissProt: P01233 Human SwissProt: Q6NT52 Human SwissProt: P0DN86 Human HCG是由胎盘合体滋养层细胞产生的一种glycoprotein激素，主要用于胎盘滋养细胞和生殖细胞Tumour如葡萄胎、绒癌的诊断和辅助诊断。
Product Picture	Measured by its binding ability in a indirect ELISA. Immobilized Human HCG Beta protein, HisTag (Cat. SL43085P) at 2 μg/mL (100 μL/well) can bind Mouse Anti-Human HCG Beta Antibody, the EC50 is 27.39 ng/mL.

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