Product Name	human IL-6
Chinese Name	白介素6单克隆抗体
Alias	Interleukin BSF 2; B cell differentiation factor; B cell stimulatory factor 2; BSF 2; BSF2; CDF; CTL differentiation factor; Cytotoxic T cell differentiation factor; Hepatocyte stimulating factor; HGF; HPGF; HSF; Hybridoma growth factor; Hybridoma plasmacytoma growth factor; IFNB2; IL 6; IL6 protein; Interferon beta 2; Interleukin 6 (interferon beta 2); Interleukin 6; Interleukin-6; Interleukin6; IL6_HUMAN.
Research Area	Tumour  Cell biology  immunology  Neurobiology  Growth factors and hormones
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	2C6
React Species	Human,
Applications	WB=1:500-2000 ELISA=1:5000-10000 ICC=1:100-500 IF=1:100-500  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	23kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	Recombinant human IL-6 protein: 30-212/212aa (C-6x His-Tag)
Lsotype	IgG
Purification	affinity purified by Protein G
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011]. Function: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. Subcellular Location: Secreted. Post-translational modifications: N- and O-glycosylated. DISEASE: Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. Similarity: Belongs to the IL-6 superfamily. SWISS: P05231 Gene ID: 3569 Database links: Entrez Gene: 3569 Human Entrez Gene: 16193 Mouse Entrez Gene: 24498 Rat Omim: 147620 Human SwissProt: P05231 Human SwissProt: P08505 Mouse SwissProt: P20607 Rat Unigene: 654458 Human Unigene: 1019 Mouse Unigene: 9873 Rat Growth factors and hormones（ Growth Factor and Hormones） 白介素-6是一种多功能cell factor，既可由lymphocyte产生，也能由非lymphocyte合成。在体内免疫反应调节、血细胞的增生、防御机制和急性期反应中起重要作用。 IL6是一种glycoprotein，它既可诱导急性期时相关蛋白的产生，也是β细胞终末分化并分泌抗体的必需因子，在免疫调节中发挥重要作用，人的IL-6的前体有212个氨基酸。成熟形态为185个氨基酸。 白细胞介素6的分子量：21KD-28KD;二聚体结构（多个亚型）：42KD-56KD
Product Picture	Sample: Lane 1: Recombinant human IL-6 protein, C-His (SL10807P) Lane 2: Recombinant human IL-6 protein, C-His (SL41177P) Primary: Anti-human IL-6 (SLM-10807M) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 23 kDa Observed band size: 15 kDa Paraformaldehyde-fixed, paraffin embedded (human liver carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (human IL-6) Polyclonal Antibody, Unconjugated (SLM-10807M) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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