Product Name	Human IgM
Chinese Name	人IgM单克隆抗体
Alias	human Immunoglobulin M.
literatures	Specific References  (1)     |     SLM-0345M has been referenced in 1 publications. [IF=8.025] Shasha Jiang. et al. CRM197-conjugated multi antigen dominant epitope for effective human cytomegalovirus vaccine development. INT J BIOL MACROMOL. 2022 Oct;:  ELISA ;  Mouse.   PubMed:36252620
Research Area	immunology
Immunogen Species	Mouse
Clonality	Monoclonal
React Species	(predicted: Human, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	Native Human IgM: full length
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences. Subcellular Location: Isoform 1: Secreted Isoform 2: Cell membrane SWISS: P01871 Gene ID: 3507
Product Picture	Paraformaldehyde-fixed, paraffin embedded (human tonsil); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (Human IgM) Monoclonal Antibody, Unconjugated (SLM-0345M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.

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