Product Name	Thymosin beta 4
Chinese Name	胸腺素β4抗体
Alias	Tβ4; FX; Hematopoietic system regulatory peptide; Prothymosin beta 4; PTMB 4; PTMB4; Seraspenide; T beta 4; T beta-4; TB4X; THYB 4; Thyb4; Thymosin beta 4; Thymosin beta 4 X chromosome; Thymosin beta 4 X linked; TMSB 4; TMSB4; TMSB4X; TYB4_HUMAN.  Tβ-4; Tβ 4.
Research Area	Cardiovascular  Signal transduction  Cytoskeleton  Extracellular matrix
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	4.8kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Thymosin beta 4: 37-44/44
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Proteins in the thymosin beta family are highly conserved polar peptides that bind monomeric Actin and thereby inhibit Actin polymerization. These proteins act as the main intracellular G-Actin sequestering peptides. The most abundant thymosin beta family member in mammalian cells and tissues is thymosin beta-4 (Tbeta-4), also designated Seraspenide. T beta-4 participates in several cellular events including cancerogenesis, apoptosis, angiogenesis, blood coagulation and would healing. Specifically, T beta-4 promotes cell migration and adhesion, accelerates wound healing and reduces inflammation, and becomes upregulated in a wide variety of human carcinomas. Due to the effects of T beta-4 in these events, it may become a protein of significant biological and pharmaceutical relevance. Function: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase. Subcellular Location: Cytoplasm, cytoskeleton. Tissue Specificity: Originally found in thymus but it is widely distributed in many tissues. Similarity: Belongs to the thymosin beta family. SWISS: P62327 Gene ID: 7114 Database links: Entrez Gene: 7114 Human Entrez Gene: 19241 Mouse Entrez Gene: 81814 Rat Omim: 300159 Human SwissProt: P62327 Horse SwissProt: P62328 Human SwissProt: P20065 Mouse SwissProt: P62329 Rat SwissProt: Q0P5V6 Rat Unigene: 437277 Human Unigene: 142729 Mouse Unigene: 409203 Mouse Unigene: 168067 Rat Unigene: 2605 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Thymosin beta 4) Polyclonal Antibody, Unconjugated (SL9870R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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