Product Name	C1orf67
Chinese Name	1号染色体开放阅读框67抗体
Alias	Chromosome 1 open reading frame 67; Coiled coil domain containing protein C1orf67; Hypothetical protein LOC200095; MGC149665; MGC149666; MGC27277; MGC51214; DYH14_HUMAN.
Research Area	Cell biology  immunology  Developmental biology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	400kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human C1orf67/DNAH14: 201-300/3507
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors; the complex transports cellular cargos towards the central region of the cell. Axonemal dynein motors contain one to three non-identical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. DNAH14 (dynein, axonemal, heavy chain 14), also known as C1orf67 or HL18, is a 3,507 amino acid member of the dynein heavy chain protein family. DNAH14 is one of the force generating protein of respiratory cilia and may be involved in sperm motility through sperm flagellar assembly. Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Subunit: Consists of at least two heavy chains and a number of intermediate and light chains. Subcellular Location: Cytoplasm, cytoskeleton, cilium axoneme (Potential). Similarity: Belongs to the dynein heavy chain family. SWISS: Q0VDD8 Gene ID: 200095 Database links: Entrez Gene: 200095 Human SwissProt: Q0VDD8 Human Unigene: 133977 Human

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