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Product Name C14orf130 Chinese Name 14号染色体开放阅读框130抗体 Alias Chromosome 14 open reading frame 130; N recognin 7; Putative E3 ubiquitin-protein ligase UBR7; Ubiquitin protein ligase E3 component n-recognin 7 (putative); UBR7; UBR 7; UBR-7; UBR7_HUMAN. Research Area Cell biology immunology Zinc finger protein Ubiquitin Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 48kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human UBR7/C14orf130: 331-425/425 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Ubr7 is a 425 amino acid protein that contains one UBR-type zinc finger and one PHD zinc finger. Participating in protein modification events within the N-end rule pathway, Ubr7 functions as an E3 ubiquitin-protein ligase that recognizes and binds proteins that contain destabilizing N-terminal residues, thereby leading to their ubiquitination and subsequent degradation.
Function:
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity).
Similarity:
Contains 1 PHD-type zinc finger.
Contains 1 UBR-type zinc finger.
SWISS:
Q8N806
Gene ID:
55148
Database links:Entrez Gene: 55148 Human
Entrez Gene: 66622 Mouse
Omim: 613816 Human
SwissProt: Q8N806 Human
SwissProt: Q8BU04 Mouse
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