Product Name	Transcription factor 25
Chinese Name	核转录因子25抗体
Alias	FKSG26; hKIAA1049; NULP1; PRO2620; Hulp1; KIAA1049; Nuclear localized protein 1; Transcription factor 25 (basic helix loop helix); TCF25_HUMAN.
Research Area	Cardiovascular  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	77kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Transcription factor 25/Nulp1: 201-300/676
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Transcription factor 25 acts as a transcriptional repressor. It has been shown to repress transcription of SRF in vitro and hence may play a role in heart development.Transcription factor 25, is a 676 amino acid protein that plays a role in cell death. A member of the TCF25 family, Nulp1 utilizes its C-terminus to mediate transcriptional repression of SRF in vitro, and interacts with XIAP. Nulp1 localizes primarily to the nucleus but is also found in cytosol. Widely expressed, Nulp1 is found at high levels in embryonic brain and adult heart. The gene encoding Nulp1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition. Function: May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development. Subunit: Interacts with XIAP (By similarity). Subcellular Location: Nuclear. Note=Some staining in the cytosol. Tissue Specificity: In the embryo, widely expressed with highest levels in brain. In the adult, highest expression is found in the heart. Similarity: Belongs to the TCF25 family. SWISS: Q9BQ70 Gene ID: 22980 Database links: Entrez Gene: 22980 Human Entrez Gene: 66855 Mouse Omim: 612326 Human SwissProt: Q9BQ70 Human SwissProt: Q8R3L2 Mouse Unigene: 415342 Human Unigene: 178818 Mouse

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