Product Name	DIF14/LMBR1
Chinese Name	分化相关基因14抗体
Alias	ACHP; C7orf2; DIF 14; DIF14; Differentiation related gene 14; Differentiation related gene 14 protein; Differentiation-related gene 14 protein; FLJ11665; Limb region 1 homolog (mouse); Limb region 1 homolog; Limb region 1 protein; Limb region 1 protein homolog; LMBR 1; LMBR1; LMBR1_HUMAN; PPD 2; PPD2; TPT.
Research Area	Cell biology  immunology  Developmental biology  Cell differentiation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	55kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LMBR1/DIF14: 301-400/490 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	LMBR1 is a 490 amino acid multi-pass membrane protein that is widely expressed with strongest expression in heart and pancreas. Belonging to the LIMR family, LMBR1 shares 95% sequence identity with the mouse protein and may play crucial role in the evolution of limb and skeletal system. LMBR1 is critical for expression of sonic hedgehog (Shh) in the developing posterior limb bud mesenchyme. Mutations in the gene encoding LMBR1 is the cause of several rare conditions such as acheiropody (ACHP) and syndactyly type 4 (SDYT4). ACHP is an autosomal recessive inherited disorder characterized by bilateral congenital amputations of the hands and feet. LMBR1L (limb region 1 protein homolog-like), also known as LIMR (Lipocalin-1-interacting membrane receptor), is a 489 amino acid multi-pass membrane protein that is thought to act as a receptor for Lipocalin-1 and may also assist in its endocytosis. Function: Putative membrane receptor. Subcellular Location: Membrane. Tissue Specificity: Widely expressed with strongest expression in heart and pancreas. DISEASE: Defects in LMBR1 are associated with preaxial polydactyly type 2 (PPD2); also known as polydactyly of triphalangeal thumb. Polydactyly consists of duplication of the distal phalanx. The thumb in PPD2 is usually opposable and possesses a normal metacarpal. The mutations do not change the normal expression of LMBR1, but alter the expression of SHH by disrupting a long-range, cis-regulatory element of that gene. Similarity: Belongs to the LIMR family. SWISS: Q8WVP7 Gene ID: 64327 Database links: Entrez Gene: 64327 Human Entrez Gene: 56873 Mouse Entrez Gene: 362295 Rat Omim: 605522 Human SwissProt: Q8WVP7 Human SwissProt: Q9JIT0 Mouse Unigene: 209989 Human
Product Picture	Sample: Urinary bladder (Mouse) Lysate at 40 ug Primary: Anti- DIF14/LMBR1 (SL9563R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 55 kD Observed band size: 55 kD Sample: Heart (Mouse) Lysate at 40 ug Primary: Anti- DIF14/LMBR1 (SL9563R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 55 kD Observed band size: 55 kD

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