Product Name	PROCR
Chinese Name	endothelial cells活化蛋白受体（CD201）抗体
Alias	EPCR_HUMAN; Endothelial protein C receptor; EPCR; Activated protein C receptor (APC receptor); CD201; protein C receptor; CCCA; CCD41;
literatures	Specific References  (3)     |     SL9506R has been referenced in 3 publications. [IF=3.24] Se Eun Ha. et al. Transcriptome profiling of subepithelial PDGFRα cells in colonic mucosa reveals several cell-selective markers. PLOS ONE. 2022 May;17(5):e0261743  IHC ;  Mouse.   PubMed:35560163 [IF=1.26] Zhao et al. Unfractionated heparin protects the protein C system against lipopolysaccharide-induced damagein vivoandin vitro. (2017) Exp.Ther.Med. 14:5515-5522  WB ;  Human.   PubMed:29285085 [IF=1.2] Zhao, Dongmei, et al. "Unfractionated heparin protects the protein C system against lipopolysaccharide‑induced damage in vivo and in vitro." Experimental and Therapeutic Medicine.  WB ;  Human.   PubMed:10.3892/etm.2017.5236
Research Area	Cardiovascular  Cell biology  immunology  Stem cells
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3ug/Test ICC=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	25kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PROCR: 1-100/238 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013] Function: Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney. Post-translational modifications: N-glycosylated. A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form. SWISS: Q9UNN8 Gene ID: 10544 Database links: Entrez Gene: 10544 Human Omim: 600646 Human SwissProt: Q9UNN8 Human Unigene: 647450 Human
Product Picture	Blank control: Mouse kidney. Primary Antibody (green line): Rabbit Anti-EPCR antibody (SL9506R) Dilution: 3μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody : Goat anti-rabbit IgG-PE Dilution: 1μg /test. Protocol The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.

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