Product Name	Brain protein CG6
Chinese Name	脑蛋白CG6抗体
Alias	Brain protein CG 6; Brain protein CG-6; Brain protein CG6; C9orf4; CG 6; CG6; chromosome 9 open reading frame 4; CI004_HUMAN; Uncharacterized protein C9orf4.
Research Area	Cell biology  Developmental biology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	37kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Brain protein CG6: 141-240/344
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	C9orf4 is a 344 amino acid single-pass membrane protein that is primarily expressed in adult and fetal brain and is weakly expressed in spinal cord, adult ovary and medulla. C9orf4 contains one DOMON domain, a predominantly β-sheet domain that is thought to aide in extracellular adhesion. The gene encoding C9orf4 maps to human chromosome 9, which consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias. Subunit: Component of the outer core of AMPAR complex. AMPARcomplex consists of an inner core made of 4 pore-forming GluA/GRIAproteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliarysubunits arranged in a twofold symmetry. One of the two pairs ofdistinct binding sites is occupied either by CNIH2, CNIH3 orCACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 orGSG1L. This inner core of AMPAR complex is complemented by outercore constituents binding directly to the GluA/GRIA proteins atsites distinct from the interaction sites of the inner coreconstituents. Outer core constituents include at least PRRT1,PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the innerand outer core serve as a platform for other, more peripherallyassociated AMPAR constituents. Alone or in combination, theseauxiliary subunits control the gating and pharmacology of the AMPARcomplex and profoundly impact their biogenesis and proteinprocessing (By similarity). Subcellular Location: Cell membrane (By similarity). Celljunction, synapse (By similarity). Tissue Specificity: Expressed in adult and fetal brain. Very weak expression in medulla, spinal cord and in adult ovary. Similarity: Contains 1 DOMON domain. SWISS: Q9P0K9 Gene ID: 23732 Database links: Entrez Gene: 23732 Human Omim: 604574 Human SwissProt: Q9P0K9 Human Unigene: 347537 Human

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