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Product Name phospho-Kv4.2 (Thr602) Chinese Name 磷酸化电压门控性钾Channel proteinKv4.2抗体 Alias p-KCND2/Kv4.2(Thr602); p-Kv4.2(Thr602); Potassium voltage-gated channel subfamily D member 2; KCD2; KCND 2; KCND2; KCND2_HUMAN; KIAA1044; Potassium voltage gated channel Shal related subfamily member 2; RK 5; RK5; Voltage gated potassium channel Kv4.2; Voltage gated potassium channel subunit Kv4.2; Voltage sensitive potassium channel; voltage-gated potassium channel Kv4.2; Voltage-gated potassium channel subunit Kv4.2; voltage-sensitive potassium channel. Product Type Phosphorylated anti Research Area Cardiovascular Neurobiology Apoptosis Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 70kDa Cellular localization The cell membrane Extracellular matrix Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthesised phosphopeptide derived from human KCND2 around the phosphorylation site of Thr602: IP(p-T)PP Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
Function:
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
Subunit:
Homotetramer or heterotetramer with KCND1 and/or KCND3. Interacts with DPP6, DLG4 and NCS1/FREQ (By similarity). Interacts with DLG1. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. The KCND2-KCNIP2 channel complex contains four KCND2 and four KCNIP2 subunits. Interacts with FLNA, FLNC and DPP10.
Subcellular Location:
Cell membrane. Cell projection > dendrite. Detected in dendrites in cultured hippocampal neurons. Association with KCNIP2 probably enhances cell surface expression.
Tissue Specificity:
Highly expressed throughout the brain. Expression is very low or absent in other tissues.
Post-translational modifications:
Phosphorylated on serine and threonine residues.
Similarity:
Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
SWISS:
Q9NZV8
Gene ID:
3751
Database links:Entrez Gene: 3751 Human
Omim: 605410 Human
SwissProt: Q9NZV8 Human
Unigene: 654739 Human
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