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Rabbit Anti-phospho-Kv4.2 (Thr602)antibody
Rabbit Anti-phospho-Kv4.2 (Thr602)antibody
p-KCND2/Kv4.2(Thr602); p-Kv4.2(Thr602); Potassium voltage-gated channel subfamily D member 2; KCD2; KCND 2; KCND2; KCND2_HUMAN; KIAA1044; Potassium voltage gated channel Shal related subfamily member 2; RK 5; RK5; Voltage gated potassium channel Kv4.2; Vo
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  • NO.:SL9443R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:(predicted: Human,Mouse,Rat,)
    Applications:WB ELISA
    concentration:1mg/ml
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Details

Product Name phospho-Kv4.2 (Thr602)
Chinese Name 磷酸化电压门控性钾Channel proteinKv4.2抗体
Alias p-KCND2/Kv4.2(Thr602); p-Kv4.2(Thr602); Potassium voltage-gated channel subfamily D member 2; KCD2; KCND 2; KCND2; KCND2_HUMAN; KIAA1044; Potassium voltage gated channel Shal related subfamily member 2; RK 5; RK5; Voltage gated potassium channel Kv4.2; Voltage gated potassium channel subunit Kv4.2; Voltage sensitive potassium channel; voltage-gated potassium channel Kv4.2; Voltage-gated potassium channel subunit Kv4.2; voltage-sensitive potassium channel.   
Product Type Phosphorylated anti 
Research Area Cardiovascular  Neurobiology  Apoptosis  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, )
Applications WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 70kDa
Cellular localization The cell membrane Extracellular matrix 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthesised phosphopeptide derived from human KCND2 around the phosphorylation site of Thr602: IP(p-T)PP 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.

Function:
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.

Subunit:
Homotetramer or heterotetramer with KCND1 and/or KCND3. Interacts with DPP6, DLG4 and NCS1/FREQ (By similarity). Interacts with DLG1. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. The KCND2-KCNIP2 channel complex contains four KCND2 and four KCNIP2 subunits. Interacts with FLNA, FLNC and DPP10.

Subcellular Location:
Cell membrane. Cell projection > dendrite. Detected in dendrites in cultured hippocampal neurons. Association with KCNIP2 probably enhances cell surface expression.

Tissue Specificity:
Highly expressed throughout the brain. Expression is very low or absent in other tissues.

Post-translational modifications:
Phosphorylated on serine and threonine residues.

Similarity:
Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.

SWISS:
Q9NZV8

Gene ID:
3751

Database links:

Entrez Gene: 3751 Human

Omim: 605410 Human

SwissProt: Q9NZV8 Human

Unigene: 654739 Human



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