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Product Name TSPAN3 Chinese Name 四分子交联体3/四旋蛋白3/四次Transmembrane protein3抗体 Alias tetraspanin 3; tetraspanin TM4 A; TM4 A; TM4A; TM4SF8; transmembrane 4 superfamily member 8; TSPAN 3; TSPAN-3; TSPAN3; TSN3_HUMAN. Research Area Cell biology immunology Signal transduction Cell differentiation Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 28kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human TSPAN3: 61-160/253 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail TSPAN3 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Two alternative transcripts encoding different isoforms have been described.
Function:
Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.
Subunit:
Interacts with claudin-11/CLDN11 and integrins.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Similarity:
Belongs to the tetraspanin (TM4SF) family.
SWISS:
O60637
Gene ID:
10099
Database links:Entrez Gene: 10099 Human
Entrez Gene: 56434 Mouse
Omim: 613134 Human
SwissProt: O60637 Human
SwissProt: Q9QY33 Mouse
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