Product Name	DCAF12
Chinese Name	睾丸癌中心体相关蛋白抗体
Alias	cancer/testis antigen 102; Centrosome-related protein TCC52; CT102; DCA12_HUMAN; DCAF12; DDB1- and CUL4-associated factor 12; TCC52; Testis cancer centrosome-related protein; WD repeat domain 40A; WD repeat-containing protein 40A; WDR40A.
Research Area	Tumour  Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	51kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DCAF12/WDR40A: 231-330/453
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. WDR40A (WD-repeat-containing protein 40A), also known as DDB1- CUL4-associated factor 12, is a 453 amino acid cytoplasmic protein that contains four WD-repeats. WDR40A is highly expressed in some cancer cell lines, lung cancer tissues and normal testis. A probable substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex, WRD40A is suggested to interact with DDB1. WDR40A is encoded by a gene mapping to human chromosome 9p13.3. Human chromosome 9 houses over 900 genes and comprises nearly 4% of the human genome. Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Subunit: Interacts with DDB1. Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Tissue Specificity: Highly expressed in lung cancer tissues and some cancer cell lines. Restricted expression in normal testis. Similarity: Belongs to the WD repeat DCAF12 family. Contains 4 WD repeats. SWISS: Q5T6F0 Gene ID: 25853 Database links: Entrez Gene: 25853 Human Entrez Gene: 68970 Mouse SwissProt: Q5T6F0 Human SwissProt: Q8BGZ3 Mouse Unigene: 493750 Human Unigene: 726117 Human Unigene: 28891 Mouse

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